Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50524256
Substrate
n/a
Meas. Tech.
ChEMBL_1892561 (CHEMBL4394482)
EC50
0.400000±n/a nM
Citation
 Shen, Y; McCorvy, JD; Martini, ML; Rodriguiz, RM; Pogorelov, VM; Ward, KM; Wetsel, WC; Liu, J; Roth, BL; Jin, J D J Med Chem 62:4755-4771 (2019) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50524256
Synonyms:
CHEMBL4451797
Type:
Small organic molecule
Emp. Form.:
C20H30ClN3O
Mol. Mass.:
363.925
SMILES:
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCc3cccc(Cl)c3C2)CC1 |r,wU:6.5,wD:9.9,(42.43,-16.68,;41.67,-15.34,;42.45,-14.01,;40.13,-15.33,;39.37,-13.99,;39.35,-16.66,;37.81,-16.65,;37.03,-17.97,;35.5,-17.96,;34.73,-16.62,;33.19,-16.61,;32.43,-15.28,;30.89,-15.27,;30.12,-13.93,;28.57,-13.93,;27.81,-15.27,;26.28,-15.27,;25.52,-16.6,;26.3,-17.93,;27.82,-17.92,;28.6,-19.25,;28.58,-16.6,;30.11,-16.6,;35.5,-15.29,;37.05,-15.31,)|
Structure:
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