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Target
Tyrosine--tRNA ligase
Ligand
BDBM50524357
Substrate
n/a
Meas. Tech.
ChEMBL_1892855 (CHEMBL4394776)
Ki
43±n/a nM
Citation
 Nautiyal, M; De Graef, S; Pang, L; Gadakh, B; Strelkov, SV; Weeks, SD; Van Aerschot, A Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur J Med Chem 173:154-166 (2019) [PubMed]  Article 
Target
Name:
Tyrosine--tRNA ligase
Synonyms:
6.1.1.1 | SYY_ECOLI | TyrRS | Tyrosine--tRNA ligase | Tyrosyl-tRNA synthetase | tyrS
Type:
PROTEIN
Mol. Mass.:
47522.37
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_117817
Residue:
424
Sequence:
MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQGYDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCLICWK
  
Inhibitor
Name:
BDBM50524357
Synonyms:
CHEMBL4558119
Type:
Small organic molecule
Emp. Form.:
C18H22N4O10S
Mol. Mass.:
486.453
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Structure:
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