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Target
Non-lysosomal glucosylceramidase
Ligand
BDBM18358
Substrate
n/a
Meas. Tech.
ChEMBL_1893572 (CHEMBL4395493)
IC50
3.0±n/a nM
Citation
 De Fenza, M; D'Alonzo, D; Esposito, A; Munari, S; Loberto, N; Santangelo, A; Lampronti, I; Tamanini, A; Rossi, A; Ranucci, S; De Fino, I; Bragonzi, A; Aureli, M; Bassi, R; Tironi, M; Lippi, G; Gambari, R; Cabrini, G; Palumbo, G; Dechecchi, MC; Guaragna, A Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. Eur J Med Chem 175:63-71 (2019) [PubMed]  Article 
Target
Name:
Non-lysosomal glucosylceramidase
Synonyms:
Beta-glucosidase | GBA2 | GBA2_HUMAN | KIAA1605 | SPG46
Type:
PROTEIN
Mol. Mass.:
104639.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435476
Residue:
927
Sequence:
MGTQDPGNMGTGVPASEQISCAKEDPQVYCPEETGGTKDVQVTDCKSPEDSRPPKETDCCNPEDSGQLMVSYEGKAMGYQVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQFTVCLRREGQTVYQQVLSLERPSVLRSWNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDDAPGGLWNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQQVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFGAKGQVHYRRYTRFFGQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVHFYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDKDHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILSRGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWEGFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKASWPKVKQGTGLRTGPMFGPKEAMANLSPE
  
Inhibitor
Name:
BDBM18358
Synonyms:
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol | N-Nonyl-DNJ
Type:
Small organic molecule
Emp. Form.:
C15H31NO4
Mol. Mass.:
289.4109
SMILES:
CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Structure:
Search PDB for entries with ligand similarity: