Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50079716
Substrate
n/a
Meas. Tech.
ChEBML_28180
IC50
45±n/a nM
Citation
 Matsuyama, N; Kosaka, T; Fukuhara, M; Soda, Y; Mizuno, K Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). Bioorg Med Chem Lett 9:2039-42 (1999) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50079716
Synonyms:
(5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hexaenoic acid (2,6-diisopropyl-phenyl)-amide | CHEMBL304267
Type:
Small organic molecule
Emp. Form.:
C34H49NO
Mol. Mass.:
487.759
SMILES:
C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)Nc1c(cccc1C(C)C)C(C)C
Structure:
Search PDB for entries with ligand similarity: