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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50525090
Substrate
n/a
Meas. Tech.
ChEMBL_1895503 (CHEMBL4397538)
Kd
30±n/a nM
Citation
 Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL Consideration of Binding Kinetics in the Design of Stapled Peptide Mimics of the Disordered Proteins Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 and Eukaryotic Translation Initiation Factor 4G. J Med Chem 62:4967-4978 (2019) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50525090
Synonyms:
CHEMBL4558213
Type:
Small organic molecule
Emp. Form.:
C97H146N24O19
Mol. Mass.:
1952.3465
SMILES:
CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@](C)(CCC\C=C/CCC[C@](C)(NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O |r,c:25|
Structure:
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