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Target
Retinoic acid receptor beta
Ligand
BDBM50080526
Substrate
n/a
Meas. Tech.
ChEBML_195832
EC50
256±n/a nM
Citation
 Dhar, A; Liu, S; Klucik, J; Berlin, KD; Madler, MM; Lu, S; Ivey, RT; Zacheis, D; Brown, CW; Nelson, EC; Birckbichler, PJ; Benbrook, DM Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids. J Med Chem 42:3602-14 (1999) [PubMed]  Article 
Target
Name:
Retinoic acid receptor beta
Synonyms:
HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50498.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458015
Residue:
455
Sequence:
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
  
Inhibitor
Name:
BDBM50080526
Synonyms:
1,4,4-Trimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid 4-ethoxycarbonyl-phenyl ester | CHEMBL422607
Type:
Small organic molecule
Emp. Form.:
C22H25NO4
Mol. Mass.:
367.4382
SMILES:
CCOC(=O)c1ccc(OC(=O)c2ccc3N(C)CCC(C)(C)c3c2)cc1
Structure:
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