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Target
Kallikrein-8
Ligand
BDBM50525899
Substrate
n/a
Meas. Tech.
ChEMBL_1898430 (CHEMBL4400465)
IC50
32±n/a nM
Citation
 Walker, AL; Denis, A; Bingham, RP; Bouillot, A; Edgar, EV; Ferrie, A; Holmes, DS; Laroze, A; Liddle, J; Fouchet, MH; Moquette, A; Nassau, P; Pearce, AC; Polyakova, O; Smith, KJ; Thomas, P; Thorpe, JH; Trottet, L; Wang, Y; Hovnanian, A Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Kallikrein-8
Synonyms:
KLK8 | KLK8_HUMAN | Kallikrein 8 | Kallikrein-8 | NP | NRPN | Neuropsin | Ovasin | PRSS19 | Serine protease 19 | Serine protease TADG-14 | TADG14 | Tumor-associated differentially expressed gene 14 protein | hK8
Type:
PROTEIN
Mol. Mass.:
28053.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_600069
Residue:
260
Sequence:
MGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGSKG
  
Inhibitor
Name:
BDBM50525899
Synonyms:
CHEMBL4465265
Type:
Small organic molecule
Emp. Form.:
C22H20BClF3N3O3
Mol. Mass.:
477.672
SMILES:
Cl.NC(=N)c1ccc(cc1OCc1cccnc1)[C@@H]1Cc2ccc(cc2B(O)O1)C(F)(F)F |r|
Structure:
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