Reaction Details Report a problem with these data
Target
Deoxyhypusine hydroxylase
Ligand
BDBM50198715
Substrate
n/a
Meas. Tech.
ChEMBL_1898739 (CHEMBL4400854)
IC50
5000±n/a nM
Citation
 Jiang, Z; You, Q; Zhang, X Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective. Eur J Med Chem 165:172-197 (2019) [PubMed]  Article 
Target
Name:
Deoxyhypusine hydroxylase
Synonyms:
1.14.99.29 | DOHH | DOHH_HUMAN | Deoxyhypusine dioxygenase | Deoxyhypusine hydroxylase | Deoxyhypusine monooxygenase | HEAT-like repeat-containing protein 1 | HLRC1 | Synonyms=HLRC1 | hDOHH
Type:
PROTEIN
Mol. Mass.:
32886.24
Organism:
Homo sapiens
Description:
ChEMBL_119191
Residue:
302
Sequence:
MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS
  
Inhibitor
Name:
BDBM50198715
Synonyms:
(2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid | CHEMBL245416 | L-mimosine
Type:
Small organic molecule
Emp. Form.:
C8H10N2O4
Mol. Mass.:
198.176
SMILES:
N[C@@H](Cn1ccc(=O)c(O)c1)C(O)=O
Structure:
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