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Target
Transient receptor potential cation channel subfamily M member 4
Ligand
BDBM50526032
Substrate
n/a
Meas. Tech.
ChEMBL_1898983 (CHEMBL4401098)
IC50
3600±n/a nM
Citation
 Delalande, C; Awale, M; Rubin, M; Probst, D; Ozhathil, LC; Gertsch, J; Abriel, H; Reymond, JL Optimizing TRPM4 inhibitors in the MHFP6 chemical space. Eur J Med Chem 166:167-177 (2019) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily M member 4
Synonyms:
Calcium-activated non-selective cation channel 1 | LTRPC4 | LTrpC-4 | Long transient receptor potential channel 4 | Melastatin-4 | TRPM4 | TRPM4_HUMAN | Transient receptor potential cation channel subfamily M member 4 | hTRPM4
Type:
PROTEIN
Mol. Mass.:
134320.63
Organism:
Homo sapiens
Description:
ChEMBL_103788
Residue:
1214
Sequence:
MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTVWDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLPPGGPPPPDLPGSKD
  
Inhibitor
Name:
BDBM50526032
Synonyms:
CHEMBL4574460
Type:
Small organic molecule
Emp. Form.:
C16H11ClN2O4
Mol. Mass.:
330.723
SMILES:
OC(=O)c1ccc(cc1NC(=O)COc1ccccc1Cl)C#N
Structure:
Search PDB for entries with ligand similarity: