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Target
Transient receptor potential cation channel subfamily M member 4
Ligand
BDBM96504
Substrate
n/a
Meas. Tech.
ChEMBL_1898983 (CHEMBL4401098)
IC50
400±n/a nM
Citation
 Delalande, C; Awale, M; Rubin, M; Probst, D; Ozhathil, LC; Gertsch, J; Abriel, H; Reymond, JL Optimizing TRPM4 inhibitors in the MHFP6 chemical space. Eur J Med Chem 166:167-177 (2019) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily M member 4
Synonyms:
Calcium-activated non-selective cation channel 1 | LTRPC4 | LTrpC-4 | Long transient receptor potential channel 4 | Melastatin-4 | TRPM4 | TRPM4_HUMAN | Transient receptor potential cation channel subfamily M member 4 | hTRPM4
Type:
PROTEIN
Mol. Mass.:
134320.63
Organism:
Homo sapiens
Description:
ChEMBL_103788
Residue:
1214
Sequence:
MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTVWDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLPPGGPPPPDLPGSKD
  
Inhibitor
Name:
BDBM96504
Synonyms:
4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)benzoic acid | 4-chloro-2-[(2-naphthalen-1-yloxyacetyl)amino]benzoic acid | 4-chloro-2-[[2-(1-naphthalenyloxy)-1-oxoethyl]amino]benzoic acid | 4-chloro-2-[[2-(1-naphthoxy)acetyl]amino]benzoic acid | MLS001123755 | SMR000665858 | cid_1295523
Type:
Small organic molecule
Emp. Form.:
C19H14ClNO4
Mol. Mass.:
355.772
SMILES:
OC(=O)c1ccc(Cl)cc1NC(=O)COc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: