Reaction Details Report a problem with these data
Target
rRNA adenine N-6-methyltransferase
Ligand
BDBM50081276
Substrate
n/a
Meas. Tech.
ChEMBL_67531 (CHEMBL679968)
Ki
12500±n/a nM
Citation
 Hajduk, PJ; Dinges, J; Schkeryantz, JM; Janowick, D; Kaminski, M; Tufano, M; Augeri, DJ; Petros, A; Nienaber, V; Zhong, P; Hammond, R; Coen, M; Beutel, B; Katz, L; Fesik, SW Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis. J Med Chem 42:3852-9 (1999) [PubMed]  Article 
Target
Name:
rRNA adenine N-6-methyltransferase
Synonyms:
ERM_STREE | ErmAM | Macrolide-lincosamide-streptogramin B resistance protein | erm
Type:
PROTEIN
Mol. Mass.:
28804.82
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_67532
Residue:
245
Sequence:
MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNIRVTLIHQDILQFQFPNKQRYKIVGSIPYHLSTQIIKKVVFESHASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLLFNGRK
  
Inhibitor
Name:
BDBM50081276
Synonyms:
CHEMBL330769 | {1-[4-Amino-6-(indan-2-ylamino)-[1,3,5]triazin-2-yl]-piperidin-3-yl}-methanol
Type:
Small organic molecule
Emp. Form.:
C18H24N6O
Mol. Mass.:
340.4228
SMILES:
Nc1nc(NC2Cc3ccccc3C2)nc(n1)N1CCCC(CO)C1
Structure:
Search PDB for entries with ligand similarity: