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Target
rRNA adenine N-6-methyltransferase
Ligand
BDBM50081300
Substrate
n/a
Meas. Tech.
ChEMBL_67531 (CHEMBL679968)
Ki
7500±n/a nM
Citation
 Hajduk, PJ; Dinges, J; Schkeryantz, JM; Janowick, D; Kaminski, M; Tufano, M; Augeri, DJ; Petros, A; Nienaber, V; Zhong, P; Hammond, R; Coen, M; Beutel, B; Katz, L; Fesik, SW Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis. J Med Chem 42:3852-9 (1999) [PubMed]  Article 
Target
Name:
rRNA adenine N-6-methyltransferase
Synonyms:
ERM_STREE | ErmAM | Macrolide-lincosamide-streptogramin B resistance protein | erm
Type:
PROTEIN
Mol. Mass.:
28804.82
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_67532
Residue:
245
Sequence:
MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNIRVTLIHQDILQFQFPNKQRYKIVGSIPYHLSTQIIKKVVFESHASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLLFNGRK
  
Inhibitor
Name:
BDBM50081300
Synonyms:
2-(3-{4-[2-Amino-6-(indan-2-ylamino)-pyrimidin-4-yl]-phenylamino}-propyl)-phenol | CHEMBL125085
Type:
Small organic molecule
Emp. Form.:
C28H29N5O
Mol. Mass.:
451.5628
SMILES:
Nc1nc(NC2Cc3ccccc3C2)cc(n1)-c1ccc(NCCCc2ccccc2O)cc1
Structure:
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