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Target
Fascin
Ligand
BDBM50526227
Substrate
n/a
Meas. Tech.
ChEMBL_1899420 (CHEMBL4401535)
IC50
510±n/a nM
Citation
 Francis, S; Croft, D; Schüttelkopf, AW; Parry, C; Pugliese, A; Cameron, K; Claydon, S; Drysdale, M; Gardner, C; Gohlke, A; Goodwin, G; Gray, CH; Konczal, J; McDonald, L; Mezna, M; Pannifer, A; Paul, NR; Machesky, L; McKinnon, H; Bower, J Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg Med Chem Lett 29:1023-1029 (2019) [PubMed]  Article 
Target
Name:
Fascin
Synonyms:
55 kDa actin-bundling protein | FAN1 | FSCN1 | FSCN1_HUMAN | HSN | SNL | Singed-like protein | p55
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54533.89
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
493
Sequence:
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
  
Inhibitor
Name:
BDBM50526227
Synonyms:
CHEMBL4574198
Type:
Small organic molecule
Emp. Form.:
C25H24Cl2N6O2
Mol. Mass.:
511.403
SMILES:
Cn1cc(NC(=O)c2cn(Cc3ccc(Cl)c(Cl)c3)c(=O)c3cnc(cc23)N2CCCCC2)cn1
Structure:
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