Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM50526626
Substrate
n/a
Meas. Tech.
ChEMBL_1900393 (CHEMBL4402615)
Ki
4700±n/a nM
Citation
 Kim, JY; Kim, JY; Jenis, J; Li, ZP; Ban, YJ; Baiseitova, A; Park, KH Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle). Bioorg Med Chem 27:2499-2507 (2019) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50526626
Synonyms:
CHEMBL4076992
Type:
Small organic molecule
Emp. Form.:
C25H20O10
Mol. Mass.:
480.4203
SMILES:
COc1cc(ccc1O)[C@@H]1Oc2c(cc(cc2O)-c2oc3cc(O)cc(O)c3c(=O)c2O)[C@H]1CO |r|
Structure:
Search PDB for entries with ligand similarity: