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Target
Glutamate receptor ionotropic, NMDA 3A
Ligand
BDBM50081750
Substrate
n/a
Meas. Tech.
ChEBML_143313
IC50
8400±n/a nM
Citation
 Wright, JL; Gregory, TF; Boxer, PA; Meltzer, LT; Serpa, KA; Wise, LD Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists. Bioorg Med Chem Lett 9:2815-8 (1999) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, NMDA 3A
Synonyms:
Glutamate [NMDA] receptor subunit 3A | Glutamate receptors; NMDA/AMPA | Grin3a | NMD3A_RAT | NMDA receptor subunit 3A-1 (GluN3A)
Type:
Protein
Mol. Mass.:
127618.95
Organism:
Rattus norvegicus (Rat)
Description:
Q9R1M7
Residue:
1135
Sequence:
MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQEGGRAGAQRDDPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRRRELPASLTTNGKADSLNVTRSSVIQELSELEKQIQVIRQELQLAVSRKTELEEYQKTNRTCES
  
Inhibitor
Name:
BDBM50081750
Synonyms:
1-[4-(1H-Imidazol-4-yl)-but-3-ynyl]-4-phenyl-piperidin-4-ol | CHEMBL432826
Type:
Small organic molecule
Emp. Form.:
C18H21N3O
Mol. Mass.:
295.3788
SMILES:
OC1(CCN(CCC#Cc2cnc[nH]2)CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: