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Target
Glutamate receptor ionotropic, NMDA 3A
Ligand
BDBM50081747
Substrate
n/a
Meas. Tech.
ChEMBL_143313 (CHEMBL753015)
IC50
67000±n/a nM
Citation
 Wright, JL; Gregory, TF; Boxer, PA; Meltzer, LT; Serpa, KA; Wise, LD Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists. Bioorg Med Chem Lett 9:2815-8 (1999) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, NMDA 3A
Synonyms:
Glutamate [NMDA] receptor subunit 3A | Glutamate receptors; NMDA/AMPA | Grin3a | NMD3A_RAT | NMDA receptor subunit 3A-1 (GluN3A)
Type:
Protein
Mol. Mass.:
127618.95
Organism:
Rattus norvegicus (Rat)
Description:
Q9R1M7
Residue:
1135
Sequence:
MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQEGGRAGAQRDDPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRRRELPASLTTNGKADSLNVTRSSVIQELSELEKQIQVIRQELQLAVSRKTELEEYQKTNRTCES
  
Inhibitor
Name:
BDBM50081747
Synonyms:
4-Benzyl-1-[4-(1H-pyrazol-4-yl)-but-3-ynyl]-piperidine | CHEMBL94717
Type:
Small organic molecule
Emp. Form.:
C19H23N3
Mol. Mass.:
293.406
SMILES:
C(CN1CCC(Cc2ccccc2)CC1)C#Cc1cn[nH]c1
Structure:
Search PDB for entries with ligand similarity: