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Target
Lysyl oxidase homolog 3
Ligand
BDBM50526721
Substrate
n/a
Meas. Tech.
ChEMBL_1901015 (CHEMBL4403237)
IC50
1250±n/a nM
Citation
 Smithen, DA; Leung, LMH; Challinor, M; Lawrence, R; Tang, H; Niculescu-Duvaz, D; Pearce, SP; Mcleary, R; Lopes, F; Aljarah, M; Brown, M; Johnson, L; Thomson, G; Marais, R; Springer, C 2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth. J Med Chem 63:2308-2324 (2020) [PubMed]  Article 
Target
Name:
Lysyl oxidase homolog 3
Synonyms:
1.4.3.- | 1.4.3.13 | LOXL | LOXL3 | LOXL3_HUMAN | Lysyl oxidase homolog 3 | Lysyl oxidase-like protein 3 | Synonyms=LOXL
Type:
PROTEIN
Mol. Mass.:
83173.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117594
Residue:
753
Sequence:
MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQII
  
Inhibitor
Name:
BDBM50526721
Synonyms:
CHEMBL4444163 | US10807974, Example 111 | US10995088, Example 111 | US11608330, Example 111
Type:
Small organic molecule
Emp. Form.:
C16H18N4O2S2
Mol. Mass.:
362.47
SMILES:
CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cnn(C)c1
Structure:
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