Reaction Details Report a problem with these data
Target
Collagenase 3
Ligand
BDBM50081855
Substrate
n/a
Meas. Tech.
ChEBML_101904
IC50
100±n/a nM
Citation
Martin, FM; Beckett, RP; Bellamy, CL; Courtney, PF; Davies, SJ; Drummond, AH; Dodd, R; Pratt, LM; Patel, SR; Ricketts, ML; Todd, RS; Tuffnell, AR; Ward, JW; Whittaker, M The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors. Bioorg Med Chem Lett 9:2887-92 (1999) [PubMed] Article
More Info.:
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
Inhibitor
Name:
BDBM50081855
Synonyms:
(2R,3R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-methyl-3-(morpholine-4-carbonyl)-hexanoic acid hydroxyamide | CHEMBL328381
Type:
Small organic molecule
Emp. Form.:
C21H27N3O6
Mol. Mass.:
417.4556
SMILES:
CC(C)C[C@H]([C@H](CN1C(=O)c2ccccc2C1=O)C(=O)NO)C(=O)N1CCOCC1