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Target
Potassium voltage-gated channel subfamily KQT member 5
Ligand
BDBM50526876
Substrate
n/a
Meas. Tech.
ChEMBL_1901610 (CHEMBL4403832)
EC50
350±n/a nM
Citation
 Ostacolo, C; Miceli, F; Di Sarno, V; Nappi, P; Iraci, N; Soldovieri, MV; Ciaglia, T; Ambrosino, P; Vestuto, V; Lauritano, A; Musella, S; Pepe, G; Basilicata, MG; Manfra, M; Perinelli, DR; Novellino, E; Bertamino, A; Gomez-Monterrey, IM; Campiglia, P; Taglialatela, M Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators. J Med Chem 63:163-185 (2020) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 5
Synonyms:
KCNQ (Kv7) potassium channel | KCNQ5 | KCNQ5_HUMAN | Voltage-gated potassium channel subunit Kv7.5
Type:
PROTEIN
Mol. Mass.:
102221.23
Organism:
Homo sapiens (Human)
Description:
ChEMBL_938650
Residue:
932
Sequence:
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDALSLPHVKLK
  
Inhibitor
Name:
BDBM50526876
Synonyms:
CHEMBL4457044
Type:
Small organic molecule
Emp. Form.:
C22H23F3N2O
Mol. Mass.:
388.426
SMILES:
CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccc(cc3)C(F)(F)F)ccc2c1
Structure:
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