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Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM50143558
Substrate
n/a
Meas. Tech.
ChEMBL_1901607 (CHEMBL4403829)
EC50
930±n/a nM
Citation
 Ostacolo, C; Miceli, F; Di Sarno, V; Nappi, P; Iraci, N; Soldovieri, MV; Ciaglia, T; Ambrosino, P; Vestuto, V; Lauritano, A; Musella, S; Pepe, G; Basilicata, MG; Manfra, M; Perinelli, DR; Novellino, E; Bertamino, A; Gomez-Monterrey, IM; Campiglia, P; Taglialatela, M Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators. J Med Chem 63:163-185 (2020) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ (Kv7) potassium channel | KCNQ2 | KCNQ2_HUMAN | KQT-like 2 | Neuroblastoma-specific potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2
Type:
PROTEIN
Mol. Mass.:
95883.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457496
Residue:
872
Sequence:
MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSPCRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
  
Inhibitor
Name:
BDBM50143558
Synonyms:
CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethylester | RETIGABINE | [2-Amino-4-(4-fluoro-benzylamino)-phenyl]-carbamic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C16H18FN3O2
Mol. Mass.:
303.3314
SMILES:
CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N
Structure:
Search PDB for entries with ligand similarity: