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Target
Lactoylglutathione lyase
Ligand
BDBM50233538
Substrate
n/a
Meas. Tech.
ChEMBL_1901788 (CHEMBL4404010)
Ki
290±n/a nM
Citation
 Jin, T; Zhao, L; Wang, HP; Huang, ML; Yue, Y; Lu, C; Zheng, ZB Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Lactoylglutathione lyase
Synonyms:
4.4.1.5 | Aldoketomutase | Glo1 | Glx I | Glyoxalase I | Ketone-aldehyde mutase | LGUL_MOUSE | Lactoylglutathione lyase | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:
PROTEIN
Mol. Mass.:
20805.83
Organism:
Mus musculus
Description:
ChEMBL_10270
Residue:
184
Sequence:
MAEPQPASSGLTDETAFSCCSDPDPSTKDFLLQQTMLRIKDPKKSLDFYTRVLGLTLLQKLDFPAMKFSLYFLAYEDKNDIPKDKSEKTAWTFSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKIATII
  
Inhibitor
Name:
BDBM50233538
Synonyms:
18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoolean-12-en-30-oic acid | CHEMBL230006 | US11660306, Example 18beta Glycyrrhetinic acid | glycyrrhetinic acid
Type:
Small organic molecule
Emp. Form.:
C30H46O4
Mol. Mass.:
470.6838
SMILES:
CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O |r,t:19|
Structure:
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