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Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Ligand
BDBM50453611
Substrate
n/a
Meas. Tech.
ChEMBL_1902016 (CHEMBL4404238)
Ki
11±n/a nM
Citation
 Peterková, L; Kmoní?ková, E; Ruml, T; Rimpelová, S Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective. J Med Chem 63:1937-1963 (2020) [PubMed]  Article 
Target
Name:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Synonyms:
7.2.2.10 | AT2A2_HUMAN | ATP2A2 | ATP2B | Calcium pump 2 | Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform | Endoplasmic reticulum class 1/2 Ca(2+) ATPase | SERCA2 | SR Ca(2+)-ATPase 2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Type:
PROTEIN
Mol. Mass.:
114736.98
Organism:
Homo sapiens
Description:
ChEMBL_11689
Residue:
1042
Sequence:
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVIWVYSTDTNFSDMFWS
  
Inhibitor
Name:
BDBM50453611
Synonyms:
CHEMBL4207081
Type:
Small organic molecule
Emp. Form.:
C34H52O9
Mol. Mass.:
604.7713
SMILES:
[H][C@@]1(O[C@H]2CC(=O)O[C@H](C\C=C\C=C\C[C@H](C)\C=C(C)\[C@H](C\C=C\2)OC)\C=C(\C)C\C=C\C)O[C@H](CO)[C@@H](O)[C@H](OC)[C@H]1O |r,c:17,t:10,12,22|
Structure:
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