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Target
Frizzled-8
Ligand
BDBM50003659
Substrate
n/a
Meas. Tech.
ChEMBL_1902347 (CHEMBL4404569)
Kd
16800±n/a nM
Citation
 Zhao, Y; Ren, J; Hillier, J; Lu, W; Jones, EY Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. J Med Chem 63:3252-3260 (2020) [PubMed]  Article 
Target
Name:
Frizzled-8
Synonyms:
FZD8_MOUSE | Frizzled-8 | Fz-8 | Fzd8 | mFz8
Type:
PROTEIN
Mol. Mass.:
73061.87
Organism:
Mus musculus
Description:
ChEMBL_119082
Residue:
685
Sequence:
MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGSGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
  
Inhibitor
Name:
BDBM50003659
Synonyms:
5H-dibenzo[b,f]azepine-5-carboxamide | CARBAMAZEPINE | CARBATROL | CHEMBL108 | DIBENZO[B,F]AZEPINE-5-CARBOXYLIC ACID AMIDE(CARBAMAZEPINE) | EPITOL | EQUETRO | G-32883 | TEGRETOL | TEGRETOL-XR | TERIL | US9138393, Carbamazepine | US9144538, Carbamazepine
Type:
Small organic molecule
Emp. Form.:
C15H12N2O
Mol. Mass.:
236.2686
SMILES:
NC(=O)N1c2ccccc2C=Cc2ccccc12 |c:11|
Structure:
Search PDB for entries with ligand similarity: