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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50082623
Substrate
n/a
Meas. Tech.
ChEMBL_201431 (CHEMBL809834)
Ki
12±n/a nM
Citation
 Carroll, FI; Bai, X; Dehghani, A; Mascarella, SW; Williams, W; Bowen, WD Asymmetric synthesis of 9-alkyl-2-benzyl-6,7-benzomorphans: characterization as novel sigma receptor ligands. J Med Chem 42:4621-9 (1999) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50082623
Synonyms:
Benzyl-[2-((1S,2R)-2-isopropyl-1,2-dihydro-naphthalen-1-yl)-ethyl]-amine | CHEMBL346665
Type:
Small organic molecule
Emp. Form.:
C22H27N
Mol. Mass.:
305.4565
SMILES:
CC(C)[C@@H]1C=Cc2ccccc2[C@H]1CCNCc1ccccc1 |c:4|
Structure:
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