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Target
Decaprenylphosphoryl-beta-D-ribose oxidase
Ligand
BDBM50528137
Substrate
n/a
Meas. Tech.
ChEMBL_1904470 (CHEMBL4406692)
IC50
158±n/a nM
Citation
 Balabon, O; Pitta, E; Rogacki, MK; Meiler, E; Casanueva, R; Guijarro, L; Huss, S; Lopez-Roman, EM; Santos-Villarejo, Á; Augustyns, K; Ballell, L; Aguirre, DB; Bates, RH; Cunningham, F; Cacho, M; Van der Veken, P Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-?-d-Ribose Oxidase (DprE1) Inhibitors. J Med Chem 63:5367-5386 (2020) [PubMed]  Article 
Target
Name:
Decaprenylphosphoryl-beta-D-ribose oxidase
Synonyms:
DPRE1_MYCTU | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | Decaprenylphosphoryl-beta-D-ribose oxidase | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1
Type:
PROTEIN
Mol. Mass.:
50167.60
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_116793
Residue:
461
Sequence:
MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKLGRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
  
Inhibitor
Name:
BDBM50528137
Synonyms:
CHEMBL4455316
Type:
Small organic molecule
Emp. Form.:
C20H15F2N3O5
Mol. Mass.:
415.347
SMILES:
CC1(NC(=O)N(CC(=O)c2ccc(F)cc2F)C1=O)c1ccc2OCC(=O)Nc2c1
Structure:
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