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Target
Proteinase-activated receptor 4
Ligand
BDBM364744
Substrate
n/a
Meas. Tech.
ChEMBL_1904769 (CHEMBL4407127)
IC50
4.2±n/a nM
Citation
 Miller, MM; Banville, J; Friends, TJ; Gagnon, M; Hangeland, JJ; Lavallée, JF; Martel, A; O'Grady, H; Rémillard, R; Ruediger, E; Tremblay, F; Posy, SL; Allegretto, NJ; Guarino, VR; Harden, DG; Harper, TW; Hartl, K; Josephs, J; Malmstrom, S; Watson, C; Yang, Y; Zhang, G; Wong, P; Yang, J; Bouvier, M; Seiffert, DA; Wexler, RR; Lawrence, RM; Priestley, ES; Marinier, A Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy. J Med Chem 62:7400-7416 (2019) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM364744
Synonyms:
6-(4-(Benzyloxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole | US9862730, Example 203
Type:
Small organic molecule
Emp. Form.:
C21H17N3O4S
Mol. Mass.:
407.442
SMILES:
COc1nn2cc(nc2s1)-c1cc2c(OCc3ccccc3)cc(OC)cc2o1
Structure:
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