Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50528798
Substrate
n/a
Meas. Tech.
ChEMBL_1906289 (CHEMBL4408647)
Ki
72±n/a nM
Citation
 Lee, H; Ahn, S; Ann, J; Ha, H; Yoo, YD; Kim, YH; Hwang, JY; Hur, KH; Jang, CG; Pearce, LV; Esch, TE; Lewin, NE; Blumberg, PM; Lee, J Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50528798
Synonyms:
CHEMBL4536869
Type:
Small organic molecule
Emp. Form.:
C30H36F4N6O3S
Mol. Mass.:
636.704
SMILES:
CN(C)C1(Cc2ccccc2)CCN(CC1)c1cc(ccc1CNC(=O)Nc1ccc(CNS(N)(=O)=O)c(F)c1)C(F)(F)F
Structure:
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