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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50529039
Substrate
n/a
Meas. Tech.
ChEMBL_1907167 (CHEMBL4409525)
IC50
>99000±n/a nM
Citation
 Mukherjee, H; Su, N; Belmonte, MA; Hargreaves, D; Patel, J; Tentarelli, S; Aquila, B; Grimster, NP Discovery and optimization of covalent Bcl-xL antagonists. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50529039
Synonyms:
CHEMBL4446373
Type:
Small organic molecule
Emp. Form.:
C34H35FN4O8S3
Mol. Mass.:
742.857
SMILES:
CS(=O)(=O)c1cc(ccc1-c1ccc(F)cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O |r|
Structure:
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