Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 4
Ligand
BDBM50529421
Substrate
n/a
Meas. Tech.
ChEMBL_1908634 (CHEMBL4410992)
IC50
290±n/a nM
Citation
 Yu, M; Ledeboer, MW; Daniels, M; Malojcic, G; Tibbitts, TT; Coeffet-Le Gal, M; Pan-Zhou, XR; Westerling-Bui, A; Beconi, M; Reilly, JF; Mundel, P; Harmange, JC Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model. ACS Med Chem Lett 10:1579-1585 (2019) [PubMed]  Article 
Target
Name:
Short transient receptor potential channel 4
Synonyms:
Short transient receptor potential channel 4 | TRPC4 | TRPC4_HUMAN | Trp-related protein 4 | hTrp-4 | hTrp4
Type:
PROTEIN
Mol. Mass.:
112112.80
Organism:
Homo sapiens
Description:
ChEMBL_118216
Residue:
977
Sequence:
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL
  
Inhibitor
Name:
BDBM50529421
Synonyms:
CHEMBL4530872
Type:
Small organic molecule
Emp. Form.:
C16H14ClF3N4O2
Mol. Mass.:
386.756
SMILES:
FC(F)(F)c1ccccc1CN1CCN(CC1=O)c1cn[nH]c(=O)c1Cl
Structure:
Search PDB for entries with ligand similarity: