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Target
Alpha-2A adrenergic receptor [16-465]
Ligand
BDBM50085679
Substrate
n/a
Meas. Tech.
ChEMBL_33680 (CHEMBL646821)
Ki
0.350000±n/a nM
Citation
 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor. J Med Chem 43:765-8 (2000) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor [16-465]
Synonyms:
ADA2A_RAT | Adra2a | Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A
Type:
G-protein coupled receptor
Mol. Mass.:
48961.69
Organism:
Rattus norvegicus (rat)
Description:
P22909[16-465]
Residue:
450
Sequence:
MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50085679
Synonyms:
4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-7-yl)-1H-imidazole | CHEMBL286269
Type:
Small organic molecule
Emp. Form.:
C11H12N2S
Mol. Mass.:
204.291
SMILES:
C1CC(c2cnc[nH]2)c2sccc2C1
Structure:
Search PDB for entries with ligand similarity: