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Target
Nicotinamide N-methyltransferase
Ligand
BDBM50530725
Substrate
n/a
Meas. Tech.
ChEMBL_1913750 (CHEMBL4416333)
Ki
32±n/a nM
Citation
 Policarpo, RL; Decultot, L; May, E; Kuzmi?, P; Carlson, S; Huang, D; Chu, V; Wright, BA; Dhakshinamoorthy, S; Kannt, A; Rani, S; Dittakavi, S; Panarese, JD; Gaudet, R; Shair, MD High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide  J Med Chem 62:9837-9873 (2019) [PubMed]  Article 
Target
Name:
Nicotinamide N-methyltransferase
Synonyms:
NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT)
Type:
Protein
Mol. Mass.:
29571.16
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
264
Sequence:
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL
  
Inhibitor
Name:
BDBM50530725
Synonyms:
CHEMBL4435314
Type:
Small organic molecule
Emp. Form.:
C25H27N7O8
Mol. Mass.:
553.524
SMILES:
N[C@@H](CC[C@@H](C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C#Cc1cc(cc2OCOc12)C(N)=O)C(O)=O |r|
Structure:
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