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Target
Ubiquitin carboxyl-terminal hydrolase 5
Ligand
BDBM50530943
Substrate
n/a
Meas. Tech.
ChEMBL_1914153 (CHEMBL4416736)
Kd
770000±n/a nM
Citation
 Mann, MK; Franzoni, I; de Freitas, RF; Tempel, W; Houliston, S; Smith, L; Vedadi, M; Arrowsmith, CH; Harding, RJ; Schapira, M Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. J Med Chem 62:10144-10155 (2019) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 5
Synonyms:
Deubiquitinating enzyme 5 | ISOT | Isopeptidase T | UBP5_HUMAN | USP5 | Ubiquitin thioesterase 5 | Ubiquitin-specific-processing protease 5
Type:
PROTEIN
Mol. Mass.:
95751.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974329
Residue:
858
Sequence:
MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTRRPKEEDPATGTGDPPRKKPTRLAIGVEGGFDLSEEKFELDEDVKIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSASRKQEVQAWDGEVRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPGEEELPDIAPPLVTPDEPKGSLGFYGNEDEDSFCSPHFSSPTSPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILPGSSGPGSTSAAADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHIDDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVAS
  
Inhibitor
Name:
BDBM50530943
Synonyms:
CHEMBL4532335
Type:
Small organic molecule
Emp. Form.:
C9H7NO3
Mol. Mass.:
177.1568
SMILES:
OC(=O)Cc1nc2ccccc2o1
Structure:
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