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Target
Ubiquitin carboxyl-terminal hydrolase 5
Ligand
BDBM50455892
Substrate
n/a
Meas. Tech.
ChEMBL_1914153 (CHEMBL4416736)
Kd
110000±n/a nM
Citation
 Mann, MK; Franzoni, I; de Freitas, RF; Tempel, W; Houliston, S; Smith, L; Vedadi, M; Arrowsmith, CH; Harding, RJ; Schapira, M Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. J Med Chem 62:10144-10155 (2019) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 5
Synonyms:
Deubiquitinating enzyme 5 | ISOT | Isopeptidase T | UBP5_HUMAN | USP5 | Ubiquitin thioesterase 5 | Ubiquitin-specific-processing protease 5
Type:
PROTEIN
Mol. Mass.:
95751.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974329
Residue:
858
Sequence:
MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTRRPKEEDPATGTGDPPRKKPTRLAIGVEGGFDLSEEKFELDEDVKIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSASRKQEVQAWDGEVRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPGEEELPDIAPPLVTPDEPKGSLGFYGNEDEDSFCSPHFSSPTSPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILPGSSGPGSTSAAADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHIDDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVAS
  
Inhibitor
Name:
BDBM50455892
Synonyms:
CHEMBL4218728
Type:
Small organic molecule
Emp. Form.:
C12H12N2O5
Mol. Mass.:
264.2341
SMILES:
COc1cc2ncn(CC(O)=O)c(=O)c2cc1OC
Structure:
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