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Target
WD repeat-containing protein 5
Ligand
BDBM50531110
Substrate
n/a
Meas. Tech.
ChEMBL_1914441 (CHEMBL4417024)
Kd
215±n/a nM
Citation
 Macdonald, JD; Chacón Simon, S; Han, C; Wang, F; Shaw, JG; Howes, JE; Sai, J; Yuh, JP; Camper, D; Alicie, BM; Alvarado, J; Nikhar, S; Payne, W; Aho, ER; Bauer, JA; Zhao, B; Phan, J; Thomas, LR; Rossanese, OW; Tansey, WP; Waterson, AG; Stauffer, SR; Fesik, SW Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J Med Chem 62:11232-11259 (2019) [PubMed]  Article 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM50531110
Synonyms:
CHEMBL4447845
Type:
Small organic molecule
Emp. Form.:
C18H16BrClN2O5S2
Mol. Mass.:
519.817
SMILES:
CS(=O)(=O)c1cc(NS(=O)(=O)c2cc(Br)cc(Cl)c2O)cc(c1)C1(CCC1)C#N
Structure:
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