Reaction Details Report a problem with these data
Target
rRNA adenine N-6-methyltransferase
Ligand
BDBM50086583
Substrate
n/a
Meas. Tech.
ChEBML_67532
Ki
>100000±n/a nM
Citation
 Hanessian, S; Sgarbi, PW Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases. Bioorg Med Chem Lett 10:433-7 (2000) [PubMed]  Article 
Target
Name:
rRNA adenine N-6-methyltransferase
Synonyms:
ERM_STREE | ErmAM | Macrolide-lincosamide-streptogramin B resistance protein | erm
Type:
PROTEIN
Mol. Mass.:
28804.82
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_67532
Residue:
245
Sequence:
MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNIRVTLIHQDILQFQFPNKQRYKIVGSIPYHLSTQIIKKVVFESHASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLLFNGRK
  
Inhibitor
Name:
BDBM50086583
Synonyms:
(2S,3R,4S,5R)-2-[4-Amino-6-(indan-2-ylamino)-[1,3,5]triazin-2-ylmethyl]-5-(4-methyl-benzyloxymethyl)-tetrahydro-furan-3,4-diol | CHEMBL436010
Type:
Small organic molecule
Emp. Form.:
C26H31N5O4
Mol. Mass.:
477.5554
SMILES:
Cc1ccc(COC[C@H]2O[C@@H](Cc3nc(N)nc(NC4Cc5ccccc5C4)n3)[C@H](O)[C@@H]2O)cc1
Structure:
Search PDB for entries with ligand similarity: