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Target
Dual specificity protein phosphatase 22
Ligand
BDBM50263036
Substrate
n/a
Meas. Tech.
ChEMBL_1914764 (CHEMBL4417347)
IC50
>100000±n/a nM
Citation
 McCullough, BS; Batsomboon, P; Hutchinson, KB; Dudley, GB; Barrios, AM Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions. J Nat Prod 82:3386-3393 (2019) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 22
Synonyms:
DUS22_HUMAN | DUSP22 | Dual specificity phosphatase 22 | Dual specificity protein phosphatase (MKPX) | Dual specificity protein phosphatase 22 | Dual specificity protein phosphatase 22 (VHX) | Dual specificity protein phosphatase VHX (VHX) | JSP1 | LMWDSP2 | MKPX | Mitogen-activated protein kinase phosphatase x | VHX
Type:
Protein
Mol. Mass.:
20915.83
Organism:
Homo sapiens (Human)
Description:
Q9NRW4
Residue:
184
Sequence:
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAAPGILKFWAFLRRL
  
Inhibitor
Name:
BDBM50263036
Synonyms:
3-Hydroxy-6-methoxy-8,8-dimethyl-1-oxo-1,3,4,7,8,9-hexahydro-cyclopenta[h]isochromene-5-carbaldehyde | CHEMBL518277
Type:
Small organic molecule
Emp. Form.:
C16H18O5
Mol. Mass.:
290.3111
SMILES:
COc1c2CC(C)(C)Cc2c2C(=O)OC(O)Cc2c1C=O
Structure:
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