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Target
Glutaminase liver isoform, mitochondrial
Ligand
BDBM50531314
Substrate
n/a
Meas. Tech.
ChEMBL_1919875 (CHEMBL4422720)
IC50
290±n/a nM
Citation
 Xu, X; Meng, Y; Li, L; Xu, P; Wang, J; Li, Z; Bian, J Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions. J Med Chem 62:1096-1115 (2019) [PubMed]  Article 
Target
Name:
Glutaminase liver isoform, mitochondrial
Synonyms:
3.5.1.2 | GA | GLS | GLS2 | GLSL_HUMAN | Glutaminase liver isoform, mitochondrial | L-glutaminase | L-glutamine amidohydrolase
Type:
PROTEIN
Mol. Mass.:
66331.64
Organism:
Homo sapiens
Description:
ChEMBL_117753
Residue:
602
Sequence:
MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV
  
Inhibitor
Name:
BDBM50531314
Synonyms:
CHEMBL4472618
Type:
Small organic molecule
Emp. Form.:
C22H34O5
Mol. Mass.:
378.5024
SMILES:
CCCCCCCCCCC[C@H](CC1=CC(=O)C=C(OC)C1=O)OC(C)=O |r,t:13,17|
Structure:
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