Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50531604
Substrate
n/a
Meas. Tech.
ChEMBL_1920496 (CHEMBL4423341)
Ki
546±n/a nM
Citation
 Uprety, R; Váradi, A; Allaoa, A; Redel-Traub, GN; Palmer, TC; Feinberg, EN; Ferris, AC; Pande, VS; Pasternak, GW; Majumdar, S Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (? Eur J Med Chem 164:241-251 (2019) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50531604
Synonyms:
CHEMBL4562437
Type:
Small organic molecule
Emp. Form.:
C26H32N4O2
Mol. Mass.:
432.5579
SMILES:
CN1CCC2(CC1)N[C@@H](CC1CNc3ccccc13)C(=O)N(C2=O)c1c(C)cccc1C |r|
Structure:
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