Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 9
Ligand
BDBM50531902
Substrate
n/a
Meas. Tech.
ChEMBL_1921367 (CHEMBL4424212)
IC50
410±n/a nM
Citation
 Buldenko, VM; Trush, VV; Kobzar, OL; Drapailo, AB; Kalchenko, VI; Vovk, AI Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases. Bioorg Med Chem Lett 29:797-801 (2019) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 9
Synonyms:
3.1.3.48 | PTN9_HUMAN | PTP-MEG2 | PTPN9 | PTPase MEG2 | Protein-tyrosine phosphatase MEG2 | Protein-tyrosine phosphatase MEG2 (PTP-Meg2) | Tyrosine-protein phosphatase non-receptor type 9
Type:
n/a
Mol. Mass.:
68030.33
Organism:
Homo sapiens (Human)
Description:
P43378
Residue:
593
Sequence:
MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
  
Inhibitor
Name:
BDBM50531902
Synonyms:
CHEMBL4569405
Type:
Small organic molecule
Emp. Form.:
C52H44O20P4S4
Mol. Mass.:
1241.049
SMILES:
Oc1c2cc(CP(O)(=O)c3ccccc3)cc1S(=O)(=O)c1cc(CP(O)(=O)c3ccccc3)cc(c1O)S(=O)(=O)c1cc(CP(O)(=O)c3ccccc3)cc(c1O)S(=O)(=O)c1cc(CP(O)(=O)c3ccccc3)cc(c1O)S2(=O)=O
Structure:
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