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Target
G protein-activated inward rectifier potassium channel 4
Ligand
BDBM50532017
Substrate
n/a
Meas. Tech.
ChEMBL_1921816 (CHEMBL4424661)
EC50
448±n/a nM
Citation
 Sharma, S; Kozek, KA; Abney, KK; Kumar, S; Gautam, N; Alnouti, Y; David Weaver, C; Hopkins, CR Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators. Bioorg Med Chem Lett 29:791-796 (2019) [PubMed]  Article 
Target
Name:
G protein-activated inward rectifier potassium channel 4
Synonyms:
CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5
Type:
PROTEIN
Mol. Mass.:
47658.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107914
Residue:
419
Sequence:
MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
  
Inhibitor
Name:
BDBM50532017
Synonyms:
CHEMBL4529580
Type:
Small organic molecule
Emp. Form.:
C20H22F3N7O
Mol. Mass.:
433.4302
SMILES:
Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(cc2)C(F)(F)F)n(n1)C1CCCCC1
Structure:
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