Reaction Details Report a problem with these data
Target
SPRY domain-containing SOCS box protein 2
Ligand
BDBM50532315
Substrate
n/a
Meas. Tech.
ChEMBL_1922845 (CHEMBL4425801)
Kd
13±n/a nM
Citation
Harjani, JR; Yap, BK; Leung, EW; Lucke, A; Nicholson, SE; Scanlon, MJ; Chalmers, DK; Thompson, PE; Norton, RS; Baell, JB Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase. J Med Chem 59:5799-809 (2016) [PubMed] Article
More Info.:
Target
Name:
SPRY domain-containing SOCS box protein 2
Synonyms:
Gene-rich cluster protein C9 | Grcc9 | SPRY domain-containing SOCS box protein 2 | SPSB2_MOUSE | SSB-2 | Spsb2 | Ssb2
Type:
PROTEIN
Mol. Mass.:
28943.57
Organism:
Mus musculus
Description:
ChEMBL_109468
Residue:
264
Sequence:
MGQTALARGSSSTPTSQALYSDFSPPEGLEELLSAPPPDLVAQRHHGWNPKDCSENIDVKEGGLCFERRPVAQSTDGVRGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQADHYAALLGSNSESWGWDIGRGKLYHQSKGLEAPQYPAGPQGEQLVVPERLLVVLDMEEGTLGYSIGGTYLGPAFRGLKGRTLYPSVSAVWGQCQVRIRYMGERRVEEPQSLLHLSRLCVRHALGDTRLGQISTLPLPPAMKRYLLYK
Inhibitor
Name:
BDBM50532315
Synonyms:
CHEMBL4474677
Type:
Small organic molecule
Emp. Form.:
C65H114N20O24
Mol. Mass.:
1559.7203
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |r|