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Target
DNA topoisomerase I
Ligand
BDBM50088251
Substrate
n/a
Meas. Tech.
ChEMBL_213104 (CHEMBL815031)
IC50
50000±n/a nM
Citation
 Molteni, V; Rhodes, D; Rubins, K; Hansen, M; Bushman, FD; Siegel, JS A new class of HIV-1 integrase inhibitors: the 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol family. J Med Chem 43:2031-9 (2000) [PubMed]  Article 
Target
Name:
DNA topoisomerase I
Synonyms:
Topoiomerase 1B
Type:
PROTEIN
Mol. Mass.:
38086.66
Organism:
Molluscum contagiosum virus subtype 1
Description:
ChEMBL_213104
Residue:
323
Sequence:
MKRFFFYKDGELFHDRKCTRRVSRSNATYEVLRHVRIPAHLHDVRVLEQTYEQAQRGLVFVGLDSKQRAQYFYGKLHVQRRHERRDAIFVRVFGIMDGLRRFIDRHLDSPEAARDSKTQLAIFLLMETSFYIRTGKMRYFRENETVGMLTLKNRHLHEEDGLLAIRFVGKDQVTHEFRVHAEDRLYVPLMRLRDADAPEAFLFSRLSERVVYRFLRTFGVRVKDLRTYGVNVTFLSSLWTNVKELPALPSARKLVALSIRQTAEAIGHSPHIARQAYMALTVLELARDASVFEHIRTLSRDEFLAFIVDYVKRRARARCPETG
  
Inhibitor
Name:
BDBM50088251
Synonyms:
4,4',7,7'-tetrabromo-3,3,3',3'-tetramethyl-1,1'-spirobi[2,3-dihydro-1H-indene]-5,5',6,6'-tetraol | CHEMBL65504
Type:
Small organic molecule
Emp. Form.:
C21H20Br4O4
Mol. Mass.:
655.997
SMILES:
CC1(C)CC2(CC(C)(C)c3c2c(Br)c(O)c(O)c3Br)c2c1c(Br)c(O)c(O)c2Br
Structure:
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