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Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM374918
Substrate
n/a
Meas. Tech.
ChEMBL_1924452 (CHEMBL4427408)
IC50
0.500000±n/a nM
Citation
 Cheng, D; Liu, J; Han, D; Zhang, G; Gao, W; Hsieh, MH; Ng, N; Kasibhatla, S; Tompkins, C; Li, J; Steffy, A; Sun, F; Li, C; Seidel, HM; Harris, JL; Pan, S Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med Chem Lett 7:676-80 (2016) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC
Type:
PROTEIN
Mol. Mass.:
52528.36
Organism:
Mus musculus
Description:
ChEMBL_941167
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM374918
Synonyms:
US10251893, Cpd 126
Type:
Small organic molecule
Emp. Form.:
C23H19N5O
Mol. Mass.:
381.4299
SMILES:
Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2ccccn2)cn1
Structure:
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