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Target
Beta-lactamase
Ligand
BDBM50088812
Substrate
n/a
Meas. Tech.
ChEBML_47848
IC50
29000±n/a nM
Citation
 Buynak, JD; Doppalapudi, VR; Rao, AS; Nidamarthy, SD; Adam, G The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. Bioorg Med Chem Lett 10:847-51 (2000) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase class C
Type:
PROTEIN
Mol. Mass.:
41618.07
Organism:
Enterobacter cloacae
Description:
ChEMBL_47855
Residue:
384
Sequence:
MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ
  
Inhibitor
Name:
BDBM50088812
Synonyms:
CHEMBL355246 | Sodium; (4S,6R)-3-methyl-4-(1-methyl-1H-tetrazol-5-ylsulfanyl)-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H13N6O5S2
Mol. Mass.:
433.442
SMILES:
CC1=C(N2[C@@H](\C(=C/c3ccccn3)C2=O)S(=O)(=O)[C@@H]1Sc1nnnn1C)C([O-])=O |t:1|
Structure:
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