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Target
Indoleamine 2,3-dioxygenase 2
Ligand
BDBM50391363
Substrate
n/a
Meas. Tech.
ChEMBL_1924802 (CHEMBL4427758)
IC50
120000±n/a nM
Citation
 Röhrig, UF; Majjigapu, SR; Caldelari, D; Dilek, N; Reichenbach, P; Ascencao, K; Irving, M; Coukos, G; Vogel, P; Zoete, V; Michielin, O 1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2). Bioorg Med Chem Lett 26:4330-3 (2016) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 2
Synonyms:
I23O2_MOUSE | IDO-2 | Ido2 | Indol1 | Indoleamine 2,3-dioxygenase-like protein 1 | Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Type:
PROTEIN
Mol. Mass.:
45256.34
Organism:
Mus musculus
Description:
ChEMBL_105489
Residue:
405
Sequence:
MEPQSQSMTLEVPLSLGRYHISEEYGFLLPNPLEALPDHYKPWMEIALRLPHLIENRQLRAHVYRMPLLDCRFLKSYREQRLAHMALAAITMGFVWQEGEGQPQKVLPRSLAIPFVEVSRNLGLPPILVHSDLVLTNWTKRNPEGPLEISNLETIISFPGGESLRGFILVTVLVEKAAVPGLKALVQGMEAIRQHSQDTLLEALQQLRLSIQDITRALAQMHDYVDPDIFYSVIRIFLSGWKDNPAMPVGLVYEGVATEPLKYSGGSAAQSSVLHAFDEFLGIEHCKESVGFLHRMRDYMPPSHKAFLEDLHVAPSLRDYILASGPGDCLMAYNQCVEALGELRSYHINVVARYIISAATRARSRGLTNPSPHALEDRGTGGTAMLSFLKSVREKTMEALLCPGA
  
Inhibitor
Name:
BDBM50391363
Synonyms:
CHEMBL2148074
Type:
Small organic molecule
Emp. Form.:
C8H6ClN3O
Mol. Mass.:
195.606
SMILES:
Oc1ccc(Cl)cc1-c1c[nH]nn1
Structure:
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