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Target
Aurora kinase B
Ligand
BDBM50533243
Substrate
n/a
Meas. Tech.
ChEMBL_1924835 (CHEMBL4427791)
IC50
8530±n/a nM
Citation
 Shin, SY; Ahn, S; Yoon, H; Jung, H; Jung, Y; Koh, D; Lee, YH; Lim, Y Colorectal anticancer activities of polymethoxylated 3-naphthyl-5-phenylpyrazoline-carbothioamides. Bioorg Med Chem Lett 26:4301-9 (2016) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50533243
Synonyms:
CHEMBL4514298
Type:
Small organic molecule
Emp. Form.:
C28H25N3O3S
Mol. Mass.:
483.581
SMILES:
COc1ccc(cc1)C1CC(=NN1C(=S)Nc1cccc(OC)c1)c1ccc2ccccc2c1O |c:11|
Structure:
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