Reaction Details Report a problem with these data
Target
Endothelin receptor type B
Ligand
BDBM50088853
Substrate
n/a
Meas. Tech.
ChEBML_64017
IC50
>25000±n/a nM
Citation
 Kraus, GA; Wang, X Synthesis and endothelin receptor binding activity of synthetic analogues of RES-1149-2. Bioorg Med Chem Lett 10:895-7 (2000) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49664.00
Organism:
Homo sapiens (Human)
Description:
ENDOTHELIN B EDNRB HUMAN::P24530
Residue:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50088853
Synonyms:
(2E,4E)-Hexa-2,4-dienoic acid (5S,7aS)-1,7a-dihydroxy-1,3,5,6,7,7a-hexahydro-isobenzofuran-5-yl ester | CHEMBL173336
Type:
Small organic molecule
Emp. Form.:
C14H18O5
Mol. Mass.:
266.2897
SMILES:
C\C=C\C=C\C(=O)O[C@H]1CC[C@@]2(O)C(O)OCC2=C1 |c:18|
Structure:
Search PDB for entries with ligand similarity: