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Target
Prothrombin
Ligand
BDBM50088932
Substrate
n/a
Meas. Tech.
ChEBML_48301
Ki
520±n/a nM
Citation
 Arnaiz, DO; Zhao, Z; Liang, A; Trinh, L; Witlow, M; Koovakkat, SK; Shaw, KJ Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors. Bioorg Med Chem Lett 10:957-61 (2000) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50088932
Synonyms:
1-(7-Carbamimidoyl-naphthalen-2-ylmethyl)-6-[1-(1-imino-ethyl)-piperidin-4-yloxy]-1H-indole-2-carboxylic acid | CHEMBL176568
Type:
Small organic molecule
Emp. Form.:
C28H29N5O3
Mol. Mass.:
483.5616
SMILES:
CC(=N)N1CCC(CC1)Oc1ccc2cc(C(O)=O)n(Cc3ccc4ccc(cc4c3)C(N)=N)c2c1
Structure:
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