Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50427222
Substrate
n/a
Meas. Tech.
ChEMBL_1925023 (CHEMBL4427979)
Ki
11±n/a nM
Citation
 Del Prete, S; Vullo, D; De Luca, V; Carginale, V; Osman, SM; AlOthman, Z; Supuran, CT; Capasso, C Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the ?-carbonic anhydrase from Plasmodium falciparum. Bioorg Med Chem Lett 26:4184-90 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50427222
Synonyms:
CHEMBL2324864
Type:
Small organic molecule
Emp. Form.:
C15H17N3O7S2
Mol. Mass.:
415.441
SMILES:
NS(=O)(=O)c1ccc(CCNS(=O)(=O)c2ccc(cc2CO)[N+]([O-])=O)cc1
Structure:
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