Reaction Details Report a problem with these data
Target
Cytosol aminopeptidase
Ligand
BDBM23971
Substrate
n/a
Meas. Tech.
ChEMBL_1927716 (CHEMBL4430788)
IC50
5200±n/a nM
Citation
 Ziemska, J; Gu?piel, A; Jarosz, J; Nasulewicz-Goldeman, A; Wietrzyk, J; Kaw?cki, R; Pypowski, K; Jaro?czyk, M; Solecka, J Molecular docking studies, biological and toxicity evaluation of dihydroisoquinoline derivatives as potential anticancer agents. Bioorg Med Chem 24:5302-5314 (2016) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
3.4.11.1 | 3.4.11.5 | 3.4.13.23 | AMPL_PIG | Cysteinylglycine-S-conjugate dipeptidase | LAP-3 | LAP3 | Leucine aminopeptidase 3 | Leucyl aminopeptidase | Proline aminopeptidase | Prolyl aminopeptidase
Type:
PROTEIN
Mol. Mass.:
56047.39
Organism:
Sus scrofa
Description:
ChEMBL_101481
Residue:
519
Sequence:
MFLLPLPAAARVAVRQLSVRRFWGPGPDAANMTKGLVLGIYSKEKEDDAPQFTSAGENFDKLVSGKLREILNISGPPLKAGKTRTFYGLHEDFSSVVVVGLGKKGAGVDDQENWHEGKENIRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDELKQKKKVVVSAKLHGSGDQEAWQRGVLFASGQNLARHLMETPANEMTPTRFAEVIEKNLKSASSKTDVHIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPDASDPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSTIVSAAKLDLPINLVGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTKQIVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLLRFSQDSA
  
Inhibitor
Name:
BDBM23971
Synonyms:
(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid | Bestatin | CHEMBL29292 | Ubenimex
Type:
Small organic molecule
Emp. Form.:
C16H24N2O4
Mol. Mass.:
308.3728
SMILES:
CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: